[血小板减少的危重症患者的死亡风险因素]

[Risk factors of mortality in critically ill patients with thrombocytopenia].

作者信息

Masrouki S, Mebazaa M S, Mestiri T, Ben Ammar M S

机构信息

Service d'anesthésie-réanimation et d'urgence, CHU Mongi-Slim, 2046 La Marsa, Tunisie.

出版信息

Ann Fr Anesth Reanim. 2004 Aug;23(8):783-7. doi: 10.1016/j.annfar.2004.05.020.

DOI:10.1016/j.annfar.2004.05.020

PMID:15345248

Abstract

OBJECTIVE

Determine predictive factors of intensive care mortality in thrombocytopenic patients.

STUDY DESIGN

Retrospective study.

PATIENTS AND METHODS

Data including the last 100 patients hospitalised in intensive care unit during period from March 2002 to January 2003 and having presented, at least one time, a platelet count <150 x 10(9)/l. Comparison between patients was realized according to the definitive issue (death or discharge from intensive care).

RESULTS

Incidence of thrombocytopenia was 27%. Mortality rate was 53%. Thrombocytopenia in admission was noted in 44% of the patients. IGS II score (OR = 1.05 and p = 0.014), sepsis (OR = 34.2 and p = 0.002) or hepatic dysfunction cases (OR = 42.5 and p = 0.026) were predictive factors of death in intensive care unit when thrombocytopenia occurred.

CONCLUSION

Our results concerning prognostic value of thrombocytopenia in intensive care unit are partly similar to those of literature with a surmortality associated to thrombocytopenia related to sepsis and hepatic dysfunction.

摘要

目的

确定血小板减少症患者重症监护死亡率的预测因素。

研究设计

回顾性研究。

患者与方法

收集2002年3月至2003年1月期间在重症监护病房住院的最后100例患者的数据，这些患者至少有一次血小板计数<150×10⁹/L。根据最终结局（死亡或从重症监护病房出院）对患者进行比较。

结果

血小板减少症的发生率为27%。死亡率为53%。44%的患者入院时存在血小板减少。当发生血小板减少症时，国际疾病严重程度评分系统（IGS）II评分（比值比[OR]=1.05，p=0.014）、脓毒症（OR=34.2，p=0.002）或肝功能不全病例（OR=42.5，p=0.026）是重症监护病房死亡的预测因素。