Cogliano Vincent James, Baan Robert A, Straif Kurt, Grosse Yann, Secretan Marie Béatrice, El Ghissassi Fatiha, Kleihues Paul
International Agency for Research on Cancer, Lyon, France.
Environ Health Perspect. 2004 Sep;112(13):1269-74. doi: 10.1289/ehp.6950.
Several national and international health agencies have established programs with the aim of identifying agents and exposures that cause cancer in humans. Carcinogen identification is an activity grounded in the scientific evaluation of the results of human epidemiologic studies, long-term bioassays in experimental animals, and other data relevant to an evaluation of carcinogenicity and its mechanisms. In this commentary, after a brief discussion of the science basis common to the evaluation of carcinogens across different programs, we discuss in more detail the principles and procedures currently used by the IARC Monographs program.
几个国家和国际卫生机构已制定了相关计划，旨在识别导致人类患癌的因素和暴露源。致癌物鉴定是一项基于对人类流行病学研究结果、实验动物长期生物测定以及其他与致癌性及其机制评估相关数据进行科学评估的活动。在本评论中，在简要讨论不同计划中致癌物评估共有的科学基础之后，我们将更详细地讨论国际癌症研究机构（IARC）专论计划目前使用的原则和程序。
