对乙酰氨基酚肝毒性：一氧化氮来救援。
Acetaminophen hepatotoxicity: NO to the rescue.
作者信息
Wallace John L
机构信息
Department of Pharmacology & Therapeutics, Mucosal Inflammation Research Group, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada.
出版信息
Br J Pharmacol. 2004 Sep;143(1):1-2. doi: 10.1038/sj.bjp.0705781.
Abstract
Severe liver injury as a result of overdose or chronic use of acetaminophen (paracetamol) remains a significant clinical problem, accounting for as much as 40% of cases of acute liver failure. The mechanisms underlying the liver injury caused by acetaminophen have become much better understood in recent years. In this issue, Fiorucci et al. report that delivery of nitric oxide (NO) in small amounts to the liver, via a novel derivative of the bile acid ursodeoxycholic acid, results in significant protection of the liver from acetaminophen-induced damage. NO appears to produce these beneficial actions through several mechanisms, including the suppression of synthesis of several proinflammatory cytokines. There is also substantial evidence that a NO-releasing derivative of acetaminophen offers several advantages over acetaminophen itself, including enhanced analgesic potency and reduced liver toxicity.
摘要
过量服用或长期使用对乙酰氨基酚（扑热息痛）导致的严重肝损伤仍是一个重大的临床问题，占急性肝衰竭病例的40%之多。近年来，对乙酰氨基酚所致肝损伤的潜在机制已得到更深入的了解。在本期杂志中，菲奥鲁奇等人报告称，通过胆汁酸熊去氧胆酸的一种新型衍生物将少量一氧化氮（NO）输送至肝脏，可显著保护肝脏免受对乙酰氨基酚诱导的损伤。NO似乎通过多种机制产生这些有益作用，包括抑制几种促炎细胞因子的合成。也有大量证据表明，一种释放NO 的对乙酰氨基酚衍生物比其本身具有诸多优势，包括增强的镇痛效力和降低的肝毒性。
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2
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3
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A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathway.对乙酰氨基酚的一种释放一氧化氮的衍生物通过作用于Fas途径的多个检查点来保护肝脏。
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An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity.熊去氧胆酸的一种一氧化氮衍生物通过抑制半胱天冬酶活性来预防Fas介导的肝损伤。
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2652-7. doi: 10.1073/pnas.041603898. Epub 2001 Feb 13.
9
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10
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