涂覆有生物活性玻璃微球的生物可吸收聚合物板。

Bioabsorbable polymer plates coated with bioactive glass spheres.

作者信息

Niiranen H, Törmälä P

机构信息

Institute of Biomaterials, Tampere University of Technology, P.O. Box 589, FIN-33101 Tampere, Finland.

出版信息

J Mater Sci Mater Med. 1999 Dec;10(12):707-10. doi: 10.1023/a:1008966820264.

DOI:10.1023/a:1008966820264

PMID:15347937

Abstract

In order to provide bioabsorbable self-reinforced poly (L/DL) lactide (P(L/DL)LA) 70 : 30 plates with osteoconductive bioactivity, spheres (125-250 microm) of a bioactive glass 13-93 were implanted onto a polymer plate preform by pressing. With appropriate pressing parameters glass spheres were firmly attached onto the polymer plate. The top of the glass spheres remained exposed. The bioactivity of the coated plates was examined in vitro with immersion in phosphate-buffered saline (PBS). Apatite was observed to precipitate on exposed glass sphere surfaces and the whole polymer surface within the first three days.

摘要

为了赋予生物可吸收的自增强聚（L/DL）丙交酯（P（L/DL）LA）70:30板骨传导生物活性，通过压制将生物活性玻璃13-93的球体（125-250微米）植入聚合物板预成型件上。在适当的压制参数下，玻璃球体牢固地附着在聚合物板上。玻璃球体的顶部保持暴露。通过浸入磷酸盐缓冲盐水（PBS）中在体外检查涂层板的生物活性。观察到在头三天内磷灰石沉淀在暴露的玻璃球体表面和整个聚合物表面上。