聚乳酸螺钉及新型含弹性髓核可吸收椎间植入物的体外性能研究

In vitro properties of PLLA screws and novel bioabsorbable implant with elastic nucleus to replace intervertebral disc.

作者信息

Ellä V, Kellomäki M, Törmälä P

机构信息

Institute of Biomaterials, Tampere University of Technology, P.O. Box 589, FIN-33101, Tampere, Finland,

出版信息

J Mater Sci Mater Med. 2005 Jul;16(7):655-62. doi: 10.1007/s10856-005-2537-1.

DOI:10.1007/s10856-005-2537-1

PMID:15965598

Abstract

The suitability of two different implant types for the replacement of the intervertebral disc was studied in vitro. Self-reinforced poly-L-lactide (SR-PLLA) screws Ø 4.5 mm were studied 24 weeks in vitro and cylindrical implants with elastic nucleus made of poly(L/D)lactide 96/4, poly(L/DL)lactide 70/30, Bioactive Glass n:o 13-93 and Polyactive 1000PEOT70PBT30 were studied 15 weeks in vitro. The cylindrical implant mimics the size and shape of the intervertebral disc. During the in vitro, there were no changes in compression properties with either implant types. The screws had sufficient modulus for intervertebral ossification in the canine model and the cylindrical implant showed also sufficient mechanical properties. These results suggest that both implant types could be used in clinical testing.

摘要

在体外研究了两种不同类型的植入物用于替代椎间盘的适用性。对直径4.5毫米的自增强聚-L-丙交酯（SR-PLLA）螺钉进行了24周的体外研究，对由聚（L/D）丙交酯96/4、聚（L/DL）丙交酯70/30、生物活性玻璃编号13-93和聚活性1000PEOT70PBT30制成的带有弹性髓核的圆柱形植入物进行了15周的体外研究。圆柱形植入物模仿了椎间盘的大小和形状。在体外实验期间，两种植入物类型的压缩性能均未发生变化。这些螺钉在犬类模型中具有足够的模量用于椎间骨化，并且圆柱形植入物也显示出足够的机械性能。这些结果表明，两种植入物类型均可用于临床试验。