Cho S B, Miyaji F, Kokubo T, Nakanishi K, Soga N, Nakamura T
Department of Material Chemistry, Faculty of Engineering, Kyoto University, Yoshida-honmachi, Sakyo-ku, Kyoto 606-01, Japan.
J Mater Sci Mater Med. 1998 May;9(5):279-84. doi: 10.1023/a:1008808828567.
The prerequisite for glasses and glass-ceramics to bond to living bone is the formation of biologically active bone-like apatite on their surfaces. It has been shown that even a pure silica gel forms the bone-like apatite on its surface in a simulated body fluid. In the present study, pore structure of silica gels prepared by hydrolysis and polycondensation of tetraethoxysilane in an aqueous solution containing polyethylene glycol was modified by 1M HNO3, and 0.1M and 1M NH4OH solution treatments. The three kinds of resultant gels all contained large amounts of silanol groups and trisiloxane rings, but differ greatly in pore structure of nanometre pore size. Irrespective of these differences, all the gels formed the bone-like apatite on their surface in the simulated body fluid. It was speculated that a certain type of structural unit of silanol groups, which is easily formed in the presence of the polyethylene glycol, is effective for the apatite formation.
眼镜和微晶玻璃与活骨结合的前提条件是在其表面形成具有生物活性的类骨磷灰石。研究表明，即使是纯硅胶在模拟体液中也会在其表面形成类骨磷灰石。在本研究中，通过在含有聚乙二醇的水溶液中水解和缩聚四乙氧基硅烷制备的硅胶的孔结构，经1M硝酸、0.1M和1M氢氧化铵溶液处理进行了改性。三种所得凝胶均含有大量的硅醇基和三硅氧烷环，但在纳米孔径的孔结构上有很大差异。尽管存在这些差异，但所有凝胶在模拟体液中其表面均形成了类骨磷灰石。据推测，在聚乙二醇存在下易于形成的某种类型的硅醇基结构单元对磷灰石的形成是有效的。
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