Jim Man-Hong, Siu Chung-Wah, Ho Hee-Hwa, Miu Ramond, Lee Stephen Wai-Luen
Department of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong.
J Invasive Cardiol. 2004 Sep;16(9):466-8.
Anomalous origin of the right coronary artery (RCA) from the left coronary sinus can cause sudden cardiac death. Whether this unique anatomical defect also predisposes to early development of coronary artery disease (CAD) remains uncertain.
Demography, cardiovascular risk factor profiles and coronary angiograms were reviewed in 1,532 consecutive patients over the past 3 years.
Thirteen patients (0.8%) had anomalous RCA from the left coronary sinus, while the rest had normal origin from the right coronary sinus. CAD was found in 9/13 anomalous RCA patients (group A) and in 795/1,519 patients with normal RCA origin (group B). There were no differences in the distributions of age, sex or cardiovascular risk factors between the two groups. The distribution of critical lesions among the 3 major coronary arteries showed no significant differences either. However, among the patients with RCA involvement, the anomalous RCA group was significantly younger (54.8 +/- 4.8 years versus 64.9 +/- 10.1 years; p = 0.022).
The anomalous RCA from left coronary sinus is associated with early development of CAD. The affected patients are 10 years younger.
右冠状动脉（RCA）起源于左冠状窦可导致心源性猝死。这种独特的解剖学缺陷是否也易引发冠状动脉疾病（CAD）的早期发展仍不确定。
回顾了过去3年中1532例连续患者的人口统计学、心血管危险因素概况和冠状动脉造影。
13例患者（0.8%）右冠状动脉起源于左冠状窦，其余患者右冠状动脉起源于右冠状窦正常。在13例右冠状动脉异常患者（A组）中有9例发现CAD，在1519例右冠状动脉起源正常的患者（B组）中有795例发现CAD。两组之间在年龄、性别或心血管危险因素分布上无差异。三大冠状动脉中严重病变的分布也无显著差异。然而，在累及右冠状动脉的患者中，右冠状动脉异常组明显更年轻（54.8±4.8岁对64.9±10.1岁；p = 0.022）。
右冠状动脉起源于左冠状窦与CAD的早期发展相关。受影响的患者年轻10岁。
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