Truax Lauren, Hendrixson Morgann, Naqvi Jaree, Trevino Julian
Department of Surgery, Wright State University Boonshoft School of Medicine, 30 E. Apple St. Suite 6258, Dayton, OH, 45409, USA.
Wright State University Boonshoft School of Medicine, Dayton, OH, USA.
Arch Dermatol Res. 2025 Jan 6;317(1):174. doi: 10.1007/s00403-024-03750-2.
This review examines the impact of oral retinoids, particularly isotretinoin, on incisional wound healing across surgical specialties. Commonly prescribed for dermatologic conditions, concerns persist regarding oral retinoids' potential adverse effects on wound healing, prompting the widespread practice of discontinuing these medications before surgery. We performed a PubMed search and analyzed research published regarding the use of oral retinoids in a variety of surgical subspecialties: dermatologic, plastic, ophthalmologic, orthopedic, ENT/otologic, and maxillofacial. Contrary to conventional practices, our review challenges the necessity of discontinuing oral retinoids before surgery in many instances based currently available research. Our literature review underscores the need for individualized risk-benefit assessment when deciding whether to hold retinoid therapy prior to surgical intervention as well as the need for more data surrounding systemic retinoids and wound healing interactions. While encouraging a reevaluation of current practices, we advocate for evidence-based decision-making in perioperative care across various surgical specialties in collaboration between dermatologists and surgeons.
本综述探讨口服维甲酸类药物，尤其是异维甲酸，对各外科专业手术切口愈合的影响。口服维甲酸类药物常用于治疗皮肤病，但其对伤口愈合的潜在不良影响一直令人担忧，这促使人们普遍在手术前停用这些药物。我们在PubMed上进行了检索，并分析了关于口服维甲酸类药物在各种外科亚专业（皮肤科、整形外科、眼科、骨科、耳鼻喉科/耳科和颌面外科）中应用的研究。与传统做法相反，我们的综述基于现有研究对许多情况下手术前停用口服维甲酸类药物的必要性提出了质疑。我们的文献综述强调，在决定手术干预前是否停止维甲酸治疗时，需要进行个体化的风险效益评估，以及需要更多关于全身性维甲酸与伤口愈合相互作用的数据。在鼓励重新评估当前做法的同时，我们主张皮肤科医生和外科医生合作，在各外科专业的围手术期护理中进行基于证据的决策。
