[Expression of a plant associated human cancer antigen in breast cancer].

作者信息

Fu Jun, Tian Hai-mei, Qu Ping, Li Mo, Zheng Xin-wen, Zheng Zhen-hai, Zhang Wei

机构信息

Medical Center for Tumor Detection, Cancer Institute (Hospital), Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100021, China.

出版信息

Zhonghua Zhong Liu Za Zhi. 2004 Jul;26(7):403-5.

OBJECTIVE

To study the expression of a glycoprotein of plant origin in normal, benign and malignant breast tissues.

METHODS

Expression of a plant glycoprotein was examined in 5 samples of normal breast tissues, 20 fibro-adenoma and 136 breast cancer by SABC immunohistochemical staining and the results were analyzed by SPSS statistics software.

RESULTS

No positive staining was detected in normal breast tissues (0/5). Weak staining was observed in 4 of 20 (20.0%) breast fibro-adenoma. Positive staining was demonstrated in 116 out of 136 (85.3%) breast cancer specimens. The differences were statistically significant. The expression of plant-associated human cancer antigen was related to pathological grade (P < 0.05), tissue invasiveness (P < 0.01) and recurrence (P < 0.05), but not to patients' age, tumor size and c-erbB-2 expression.

CONCLUSION

The plant glycoprotein studied may be a human cancer-associated antigen which might be a potential marker of breast cancer.