Logullo Angela F, Lopes Andreia B G, Nonogaki Suely, Soares Fernando A, Netto Mário Mourão, Nishimoto Inês N, Brentani M Mitzi
Departamento de Patologia da Universidade Federal de São Paulo, São Paulo, Brazil.
Oncol Rep. 2007 Jul;18(1):121-6.
The definition of high risk patients with early stage breast cancer is still controversial. We evaluated the ability of galectin-3, c-erbB-2 and p53 immunohistochemical expression to predict recurrence and survival in a homogeneous set of 92 patients with T1N0M0 ductal carcinoma with a long-term follow-up. In normal breast tissue, the epithelial and fibroblast components were positive for galectin-3 mostly showing nuclear and cytoplasmic reactivity. At the tumor epithelial component, galectin-3 expression was found in 46.7% of the samples with a predominant cytoplasmic staining. Similar results were presented by concurrent in situ lesions. Tumor stromal fibroblasts maintained positivity in 70 out of 92 cases (76%). We found expression of p53 in only 16 cases (17.4%), and c-erbB-2 in 17 (18.48%). A marginal association was found between co-expression of p53 and galectin-3 (p=0.055) and a significant correlation between p53 accumulation and c-erbB-2 expression (p=0.009). There was no significant association between galectin-3 protein expression with disease-free survival or overall survival. C-erbB2 and p53 expression correlated with recurrence (p=0.002, p=0.02; respectively). Diminished overall survival at 10 years was associated with c-erbB-2 (p=0.010), but marginally with p53 expression (p=0.076). Epithelial galectin-3 expression cannot be considered a prognostic factor for patients with T1N0M0 breast cancer, p53 seems to be of minor relevance and c-erbB-2 expression was the best discriminator and may be a marker for aggressive clinical behavior in patients with early stage breast cancer.
早期乳腺癌高危患者的定义仍存在争议。我们评估了半乳糖凝集素-3、c-erbB-2和p53免疫组化表达在一组92例T1N0M0导管癌患者中的预测复发和生存的能力，这些患者均接受了长期随访。在正常乳腺组织中，上皮和纤维母细胞成分半乳糖凝集素-3呈阳性，大多表现为核和胞质反应性。在肿瘤上皮成分中，46.7%的样本中发现半乳糖凝集素-3表达，主要为胞质染色。同时存在的原位病变也呈现类似结果。肿瘤间质纤维母细胞在92例中有70例（76%）保持阳性。我们仅在16例（17.4%）中发现p53表达，17例（18.48%）中发现c-erbB-2表达。p53和半乳糖凝集素-3的共表达之间存在边缘关联（p = 0.055），p53积聚与c-erbB-2表达之间存在显著相关性（p = 0.009）。半乳糖凝集素-3蛋白表达与无病生存期或总生存期之间无显著关联。C-erbB2和p53表达与复发相关（分别为p = 0.002，p = 0.02）。10年总生存期降低与c-erbB-2相关（p = 0.010），但与p53表达存在边缘关联（p = 0.076）。上皮半乳糖凝集素-3表达不能被视为T1N0M0乳腺癌患者的预后因素，p53似乎相关性较小，而c-erbB-2表达是最佳鉴别指标，可能是早期乳腺癌患者侵袭性临床行为的标志物。
