由带有二膦亚基环丁烯配体的（π-烯丙基）钯配合物催化的芳基溴化物在室温下的无溶剂胺化反应。

Solvent free amination reactions of aryl bromides at room temperature catalyzed by a (pi-allyl)palladium complex bearing a diphosphinidenecyclobutene ligand.

作者信息

Gajare Anil S, Toyota Kozo, Yoshifuji Masaaki, Ozawa Fumiyuki

机构信息

Department of Chemistry, Graduate School of Science, Tohoku University, Aoba, Sendai 980-8578, Japan.

出版信息

J Org Chem. 2004 Sep 17;69(19):6504-6. doi: 10.1021/jo049087n.

DOI:10.1021/jo049087n

PMID:15357620

Abstract

An air- and moisture-stable (pi-allyl)palladium complex bearing a unique diphosphinidenecyclobutene ligand effectively catalyzes amination reactions of aryl bromides with amines, where the reactions proceed under mild conditions without solvent, with 2 mol % of catalyst and 1 equiv of t-BuOK at room temperature. Under these conditions the amination products were obtained in good to excellent isolated yields.

摘要

一种带有独特二膦亚基环丁烯配体的对空气和湿气稳定的（π-烯丙基）钯配合物能有效催化芳基溴与胺的胺化反应，该反应在温和条件下无溶剂进行，室温下使用2摩尔%的催化剂和1当量的叔丁醇钾。在这些条件下，胺化产物的分离产率良好至优异。