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钯催化芳基溴化物与O-高烯丙基羟胺的顺序一锅反应：N-芳基-β-氨基醇的合成

Palladium-catalyzed sequential one-pot reaction of aryl bromides with O-homoallylhydroxylamines: synthesis of N-aryl-beta-amino alcohols.

作者信息

Peng Jinsong, Jiang Dahong, Lin Wenqing, Chen Yuanwei

机构信息

Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China.

出版信息

Org Biomol Chem. 2007 May 7;5(9):1391-6. doi: 10.1039/b701509g. Epub 2007 Mar 21.

DOI:10.1039/b701509g
PMID:17464408
Abstract

The palladium-catalyzed sequential one-pot N-arylation-carbo-amination-C-arylation of O-homoallylhydroxylamines with two different aryl bromides provides rapid entry to differentially arylated N-aryl-3-arylmethylisoxazolidines in good yields with excellent diastereoselectivity. The obtained isoxazolidines can be reductively cleaved to cis-N-aryl-beta-amino alcohols in short times and in high yields at room temperature.

摘要

钯催化的邻高烯丙基羟胺与两种不同芳基溴的顺序一锅法N-芳基化-碳胺化-C-芳基化反应，能够以良好的产率和优异的非对映选择性快速合成不同芳基化的N-芳基-3-芳基甲基异恶唑烷。所得到的异恶唑烷在室温下短时间内即可高产率地还原裂解为顺式-N-芳基-β-氨基醇。

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Palladium-catalyzed sequential one-pot reaction of aryl bromides with O-homoallylhydroxylamines: synthesis of N-aryl-beta-amino alcohols.钯催化芳基溴化物与O-高烯丙基羟胺的顺序一锅反应：N-芳基-β-氨基醇的合成
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引用本文的文献

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