Kwong Fuk Yee, Buchwald Stephen L
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Org Lett. 2003 Mar 20;5(6):793-6. doi: 10.1021/ol0273396.
[reaction: see text] An efficient copper-catalyzed amination of aryl bromides with primary alkylamines was developed that uses commercially available diethylsalicylamide as the ligand. This amination reaction can be performed at 90 degrees C in good yield. A variety of functional groups are compatible with these reaction conditions. Preliminary results show that this reaction can be carried out under solvent-free conditions with comparable yields.
[反应：见正文] 开发了一种高效的铜催化芳基溴与伯烷基胺的胺化反应，该反应使用市售的二乙基水杨酰胺作为配体。这种胺化反应可以在90℃下进行，产率良好。多种官能团与这些反应条件兼容。初步结果表明，该反应可以在无溶剂条件下进行，产率相当。
