[血管内皮生长因子和碱性成纤维细胞生长因子在甲状腺癌中的表达及临床意义]

[Clinical significance of expression of VEGF and bFGF in thyroid carcinoma].

作者信息

Tian Xiao-feng, Zhang Xue-wen, Chen Rui-xin, Wang Jian-wei, Zhang Dan

机构信息

Department of General Surgery, The Chinese-Japan Union Hospital of Jilin University, Changchun 130021, China.

出版信息

Zhonghua Wai Ke Za Zhi. 2004 Jul 22;42(14):864-6.

PMID:15363277

Abstract

OBJECTIVE

To study the clinical significance of expression of VEGF and bFGF in thyroid carcinoma.

METHODS

Immunohistochemical SP technic was used to investigate the expression of VEGF and bFGF in 90 cases of papillary carcinoma, 14 cases of undifferentiated carcinoma, 10 cases of normal thyroid tissue.

RESULTS

The positive rate of VEGF and bFGF in thyroid carcinoma was 63.5% and 59.6% respectively, Which was significantly higher than that in normal thyroid tissue (P < 0.01); The positive rate of VEGF and bFGF in undifferentiated carcinoma was 92.9% and 85.7% respectively, which was significantly higher than that in papillary carcinoma (P < 0.05); The positive rate of expression of VEGF and bFGF was correlated with lymph gland metastasis (P < 0.05); A positive correlation between these two expresses existed in thyroid carcinoma (gamma = 0.596, P < 0.05).

CONCLUSION

VEGF and bFGF can be regarded as a parameter to evaluate the biological behavior and prognosis of thyroid carcinoma.

摘要

目的

研究血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（bFGF）在甲状腺癌中的表达及其临床意义。

方法

采用免疫组织化学SP法检测90例乳头状癌、14例未分化癌及10例正常甲状腺组织中VEGF和bFGF的表达。

结果

甲状腺癌组织中VEGF和bFGF的阳性表达率分别为63.5%和59.6%，显著高于正常甲状腺组织（P<0.01）；未分化癌组织中VEGF和bFGF的阳性表达率分别为92.9%和85.7%，显著高于乳头状癌（P<0.05）；VEGF和bFGF的表达与淋巴结转移相关（P<0.05）；甲状腺癌组织中VEGF与bFGF的表达呈正相关（γ=0.596，P<0.05）。