人类对英国炭疽疫苗免疫反应的特征分析。
Characterization of the human immune response to the UK anthrax vaccine.
作者信息
Baillie Les, Townend Tim, Walker Nicki, Eriksson Ulla, Williamson Diane
机构信息
Biodefense Vaccines, Biological Defense Research Directorate, Naval Medical Research Center, Silver Spring, MD 20910-7500, USA.
出版信息
FEMS Immunol Med Microbiol. 2004 Oct 1;42(2):267-70. doi: 10.1016/j.femsim.2004.05.011.
The anthrax bipartite lethal toxin (protective antigen (PA) and lethal factor (LF))-specific antibody responses of humans receiving the UK licensed anthrax vaccine were determined. The PA-specific IgG response peaked two weeks post immunization and fell back to pre-boost levels by week 12. The heterogeneity of the host population modulated the extent of the PA-specific antibody response. Significantly lower levels of LF-specific antibodies were also detected. Vaccinated individuals recognized the same PA epitope as the protective mouse lethal toxin neutralizing monoclonal 2D3 suggesting that this may also be a target for human protection.
对接种英国许可的炭疽疫苗的人群的炭疽二分致死毒素（保护性抗原（PA）和致死因子（LF））特异性抗体反应进行了测定。PA特异性IgG反应在免疫后两周达到峰值，并在第12周回落至加强前水平。宿主群体的异质性调节了PA特异性抗体反应的程度。还检测到LF特异性抗体水平显著较低。接种疫苗的个体识别出与保护性小鼠致死毒素中和单克隆抗体2D3相同的PA表位，这表明该表位也可能是人类保护的靶点。
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