Choi K M, Lee K W, Seo J A, Oh J H, Kim S G, Kim N H, Choi D S, Baik S H
Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University Guro Hospital, Korea University, 80 Guro-Dong, Guro-Gu, Seoul 152-050, South Korea.
Diabetes Res Clin Pract. 2004 Oct;66(1):57-61. doi: 10.1016/j.diabres.2004.02.014.
In this study, we investigated the association between brachial-ankle pulse wave velocity (baPWV), a novel non-invasive means of measuring atherosclerosis, and the cardiovascular risk factors of the metabolic syndrome. The study group comprised of 368 Koreans without history of diabetes or hypertension. Anthropometric parameters, blood pressure, fasting blood glucose (FBG), lipid profiles, ankle-brachial pressure index (ABI), and baPWV were measured in each subject. ABI and baPWV levels were higher in men than in women. ABI and baPWV levels were not correlated with each other. In women, baPWV was closely associated with the cardiovascular risk factors of the metabolic syndrome. Women with the metabolic syndrome showed higher baPWV levels compared to those without the metabolic syndrome (1540 +/- 281 versus 1312 +/- 223, P < 0.001). Multiple regression analysis showed that baPWV was significantly associated with systolic blood pressure, age, sex, waist circumference, and FBG (adjusted R2 = 0.548). The present study shows that baPWV is significantly associated with the features of the metabolic syndrome in Korean women.
在本研究中，我们调查了测量动脉粥样硬化的一种新型非侵入性手段——臂踝脉搏波速度（baPWV）与代谢综合征的心血管危险因素之间的关联。研究组由368名无糖尿病或高血压病史的韩国人组成。对每位受试者测量人体测量学参数、血压、空腹血糖（FBG）、血脂谱、踝臂血压指数（ABI）和baPWV。男性的ABI和baPWV水平高于女性。ABI和baPWV水平彼此不相关。在女性中，baPWV与代谢综合征的心血管危险因素密切相关。患有代谢综合征的女性与未患代谢综合征的女性相比，baPWV水平更高（1540±281对1312±223，P<0.001）。多元回归分析显示，baPWV与收缩压、年龄、性别、腰围和FBG显著相关（调整R2 = 0.548）。本研究表明，baPWV与韩国女性代谢综合征的特征显著相关。
