Chung Hye Soo, Lee Hyun Jung, Hwang Soon Young, Choi Ju-Hee, Yoo Hye Jin, Seo Ji A, Kim Sin Gon, Kim Nan Hee, Choi Dong Seop, Baik Sei Hyun, Choi Kyung Mook
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
Division of Endocrinology and Metabolism, Departments of Internal Medicine, Korea University, Seoul, Republic of Korea.
Int J Endocrinol. 2018 Dec 24;2018:7918714. doi: 10.1155/2018/7918714. eCollection 2018.
Previous studies have suggested the existence of distinct body size subgroups according to metabolic health referred to as metabolically healthy obesity (MHO) and metabolically abnormal but normal weight (MANW) patients. Although nonalcoholic fatty liver disease (NAFLD) is strongly associated with obesity and metabolic syndrome, the relationship between these phenotypes and fetuin-A, a representative hepatokine, has not been explored.
We examined the association between circulating fetuin-A levels, metabolic health phenotypes, cardiometabolic risk parameters, and subclinical atherosclerosis in 290 subjects who were randomly selected from an ongoing cohort study.
Fetuin-A concentrations were significantly associated with detrimental anthropometric and laboratory measurements, including increased waist circumference, blood pressure, alanine aminotransferase, fasting plasma glucose, and triglyceride levels. Furthermore, fetuin-A levels were significantly increased in the metabolically abnormal (MA) group compared to the metabolically healthy (MH) group in subjects without obesity (717.1 [632.1, 769.7] vs. 599.5 [502.0, 709.3], = 0.001) and subjects with obesity (704.1 [595.5-880.9] vs. 612.2 [547.9-802.1], = 0.016). In addition, brachial-ankle pulse wave velocity (baPWV), which reflects arterial stiffness, was higher in MA individuals compared to MH individuals. Multiple logistic regression analysis revealed that both individuals without obesity ( for trend = 0.017) and with obesity ( for trend = 0.028) in the higher tertiles of fetuin-A had an increased risk of MA than those in the lowest tertile.
This study demonstrates that fetuin-A levels are significantly associated with metabolic health phenotypes, such as MHO and MANW, in Korean adults.
先前的研究表明，根据代谢健康状况存在不同的体型亚组，即代谢健康型肥胖（MHO）和代谢异常但体重正常（MANW）患者。尽管非酒精性脂肪性肝病（NAFLD）与肥胖和代谢综合征密切相关，但这些表型与代表性肝因子胎球蛋白-A之间的关系尚未得到探讨。
我们在一项正在进行的队列研究中随机选取了290名受试者，检测了循环胎球蛋白-A水平、代谢健康表型、心脏代谢风险参数和亚临床动脉粥样硬化之间的关联。
胎球蛋白-A浓度与有害的人体测量和实验室指标显著相关，包括腰围增加、血压升高、丙氨酸转氨酶、空腹血糖和甘油三酯水平升高。此外，在无肥胖的受试者中，代谢异常（MA）组的胎球蛋白-A水平显著高于代谢健康（MH）组（717.1[632.1,769.7]对599.5[502.0,709.3]，P = 0.001）；在肥胖受试者中也是如此（704.1[595.5 - 880.9]对612.2[547.9 - 802.1]，P = 0.016）。此外，反映动脉僵硬度的臂踝脉搏波速度（baPWV）在MA个体中高于MH个体。多因素logistic回归分析显示，胎球蛋白-A处于较高三分位数的无肥胖个体（趋势P = 0.017）和肥胖个体（趋势P = 0.028）发生MA的风险均高于最低三分位数者。
本研究表明，在韩国成年人中，胎球蛋白-A水平与MHO和MANW等代谢健康表型显著相关。
