Liu John H K, Kripke Daniel F, Weinreb Robert N
Hamilton Glaucoma Center and Department of Ophthalmology, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0946, USA.
Am J Ophthalmol. 2004 Sep;138(3):389-95. doi: 10.1016/j.ajo.2004.04.022.
To compare the nocturnal effects of once-daily timolol and latanoprost on intraocular pressure (IOP) in patients with ocular hypertension or early glaucomatous changes.
Prospective, open-label, experimental study with crossover design.
Eighteen patients with ocular hypertension or early glaucomatous changes (aged 41 to 79 years) each received topical treatments with timolol (0.5% Timoptic-XE), latanoprost (0.005% Xalatan), and no IOP-lowering medication, for at least 4 weeks. Timolol was given once in the morning upon awakening and latanoprost once in the evening at bedtime. At the end of each treatment period, the patient was housed in a sleep laboratory for 24 hours and IOP was measured every 2 hours using a pneumatonometer. Measurements were taken sitting and supine during the 16-hour diurnal/wake period and only supine during the 8-hour nocturnal/sleep period. Mean diurnal and nocturnal IOP levels were compared among the treatments with timolol, latanoprost, and no medication.
In the diurnal period, the mean IOP under the timolol or the latanoprost treatment was significantly less than the mean IOP under no medication in both the sitting and the supine positions. There was no statistical difference between the timolol and latanoprost treatments. In the nocturnal period, supine IOP with timolol treatment was not different from the supine IOP with no medication but was significantly higher than supine IOP with the latanoprost treatment.
Although both once-daily timolol and latanoprost were effective in lowering IOP during the diurnal period, only latanoprost reduced IOP during the nocturnal period.
比较一日一次使用噻吗洛尔和拉坦前列素对高眼压症或早期青光眼性病变患者夜间眼压（IOP）的影响。
前瞻性、开放标签、采用交叉设计的实验研究。
18例高眼压症或早期青光眼性病变患者（年龄41至79岁）分别接受噻吗洛尔（0.5%噻吗心安-XE）、拉坦前列素（0.005%适利达）局部治疗，且至少4周不使用降低眼压的药物。噻吗洛尔于早晨醒来时给药一次，拉坦前列素于晚上睡前给药一次。在每个治疗期结束时，患者在睡眠实验室住24小时，使用气动眼压计每2小时测量一次眼压。在16小时的白天/清醒期测量坐位和平卧位眼压，在8小时的夜间/睡眠期仅测量平卧位眼压。比较噻吗洛尔、拉坦前列素治疗组和未用药组的昼夜平均眼压水平。
在白天，噻吗洛尔或拉坦前列素治疗组的平均眼压在坐位和平卧位均显著低于未用药组。噻吗洛尔和拉坦前列素治疗组之间无统计学差异。在夜间，噻吗洛尔治疗组的平卧位眼压与未用药组的平卧位眼压无差异，但显著高于拉坦前列素治疗组的平卧位眼压。
虽然一日一次使用噻吗洛尔和拉坦前列素在白天均能有效降低眼压，但只有拉坦前列素在夜间能降低眼压。
