鼻腔恶性黑色素瘤：16例日本患者的报告
Malignant melanoma of nasal cavity: report of 16 Japanese patients.
作者信息
Nakaya Muneo, Mochiki Masato, Takeuchi Satoshi, Yuge Tadashi, Nakao Kazunari, Nakamura Naoki, Sugasawa Masashi
机构信息
Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Hongo 7-3-1 Bunkyo-ku, Tokyo 113-8655, Japan.
出版信息
Auris Nasus Larynx. 2004 Sep;31(3):233-7. doi: 10.1016/j.anl.2004.03.001.
BACKGROUND
Primary malignant melanoma of the nasal cavity is a rare disease that has a poor prognosis. There are significant racial differences in the incidence of melanomas in the nasal cavity.
METHODS
Sixteen Japanese patients treated at the Hospital of Tokyo University were reviewed retrospectively.
RESULTS
Fourteen patients were treated with surgery. Two patients received treatment with radiotherapy alone. Seven patients had microscopically negative surgical margins and seven patients had positive surgical margins. The 2- and 5-year actuarial survival rates for all patients were 63.6 and 31.8%, respectively. No statistically significant difference could be shown in the overall survival rate between patients with positive surgical margins and those with negative surgical margins.
CONCLUSIONS
Clinical features of nasal melanoma in Japanese are not different from nasal melanoma in Caucasians. The negative surgical margins were not predictive of a better prognosis.
背景
鼻腔原发性恶性黑色素瘤是一种罕见疾病，预后较差。鼻腔黑色素瘤的发病率存在显著的种族差异。
方法
对东京大学医院治疗的16例日本患者进行回顾性分析。
结果
14例患者接受了手术治疗。2例患者仅接受了放射治疗。7例患者手术切缘镜下阴性，7例患者手术切缘阳性。所有患者的2年和5年精算生存率分别为63.6%和31.8%。手术切缘阳性患者和阴性患者的总生存率无统计学显著差异。
结论
日本鼻腔黑色素瘤的临床特征与白种人鼻腔黑色素瘤无异。手术切缘阴性并不能预示更好的预后。
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