Miu Andrei C, Olteanu Adrian I, Chiş Irina, Heilman Renata M
Laboratory of Cognitive Neuroscience, Department of Psychology, Babeş-Bolyai University, 37 Republicii, Cluj-Napoca CJ 3400, Romania.
Behav Brain Res. 2004 Dec 6;155(2):223-9. doi: 10.1016/j.bbr.2004.04.019.
This study investigated the capacity of erythropoietin (EPO) to protect fear conditioning performances against functional inactivation of the amygdala. We infused an excitotoxic dose of glutamate in the lateral nucleus of the amygdala (LA) of adult rats in order to block the output projections to brainstem areas controlling the expression of conditioned fear responses. Subsequently, animals with excitotoxic lesions in the LA displayed altered short and long-term fear conditioned responses, but the integrity of their general emotional reactivity was preserved, as indicated by their open-field behavior. EPO infused immediately after glutamate succeeded to protect the conditioned fear performances of rats. This effect was reliably represented on both short, and long-term memory tests of conditioned fear. This and other studies have supported the potent neuroprotective activity of EPO, discriminable both morphologically, and behaviorally.
本研究调查了促红细胞生成素（EPO）保护恐惧条件反射行为免受杏仁核功能失活影响的能力。我们向成年大鼠杏仁核外侧核（LA）注入兴奋性毒性剂量的谷氨酸，以阻断其向控制条件恐惧反应表达的脑干区域的输出投射。随后，LA区有兴奋性毒性损伤的动物表现出短期和长期恐惧条件反应的改变，但如旷场行为所示，其一般情绪反应的完整性得以保留。谷氨酸注入后立即注入EPO成功保护了大鼠的条件恐惧行为。这种效应在条件恐惧的短期和长期记忆测试中均得到可靠体现。本研究及其他研究均支持了EPO强大的神经保护活性，这在形态学和行为学上均可辨别。
