Aminophylline hypersensitivity apparently due to ethylenediamine.

Asthmatic patients receive multiple drugs as part of their treatment program. When a subsequent allergic reaction occurs, the ethylenediamine component of aminophylline is usually not suspected as the etiologic agent. We present a case of ethylenediamine-induced delayed hypersensitivity reaction in a 46-year-old woman who received parenteral aminophylline for an acute asthma exacerbation. Patch testing for ethylenediamine was positive.