Durkin Michelle M, Connolly Patricia A, Karimi Kian, Wheat Emerson, Schnizlein-Bick Carol, Allen Stephen D, Alves Katia, Tewari Ram P, Keath Elizabeth
MiraVista Diagnostics/MiraBella Technologies, 4444 Decatur Blvd, Suite 300, Indianapolis, IN 46241, USA.
J Clin Microbiol. 2004 Sep;42(9):4370-3. doi: 10.1128/JCM.42.9.4370-4373.2004.
Clinical differences in histoplasmosis between North America and Brazil prompted investigation of experimental infection with representative strains. Mortality was higher with Latin American strains, and lung pathology showed large necrotizing granuloma with prominent neutrophilic infiltration. Chronic disease was unique to the North American strain.
北美和巴西组织胞浆菌病的临床差异促使人们对用代表性菌株进行实验性感染展开研究。拉丁美洲菌株导致的死亡率更高,肺部病理学显示有大型坏死性肉芽肿,并伴有显著的嗜中性粒细胞浸润。慢性病是北美菌株所特有的。