Meierkord H, Shorvon S, Lightman S, Trimble M
Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom.
Arch Neurol. 1992 Mar;49(3):225-30. doi: 10.1001/archneur.1992.00530270039016.
The acute effects of partial (focal) epileptic seizures on serum prolactin levels were studied in two groups of patients: (1) 10 with temporal lobe seizures and (2) 11 with seizures that arose from the frontal lobes, recorded on cable video-electroencephalographic telemetry. Six of the eight complex partial seizures of temporal lobe origin were associated with a marked rise in prolactin levels at 10 minutes after onset (rise in levels, from a mean of 279 to 534 mU/L), compared with a rise in only one of the eight frontal lobe complex partial seizures. None of the five simple partial seizures (two of temporal and three of frontal lobe origin) was associated with a marked rise in prolactin levels. This difference in prolactin response following complex partial seizures of frontal and temporal lobe origin may help in the clinical differentiation of these seizures. A failure of prolactin levels to rise does not, however, exclude a diagnosis of complex partial seizures; thus, this measurement will not help in the clinical differentiation of frontal lobe complex partial seizures from psychogenic attacks.
在两组患者中研究了部分性（局灶性）癫痫发作对血清催乳素水平的急性影响：（1）10例颞叶癫痫患者和（2）11例额叶癫痫发作患者，通过有线视频脑电图遥测记录发作情况。起源于颞叶的8次复杂部分性发作中有6次在发作后10分钟时催乳素水平显著升高（水平从平均279 mU/L升至534 mU/L），而起源于额叶的8次复杂部分性发作中只有1次出现升高。5次简单部分性发作（2次起源于颞叶，3次起源于额叶）均未伴有催乳素水平的显著升高。额叶和颞叶起源的复杂部分性发作后催乳素反应的这种差异可能有助于这些发作的临床鉴别。然而，催乳素水平未升高并不能排除复杂部分性发作的诊断；因此，这项检测无助于额叶复杂部分性发作与心因性发作的临床鉴别。
