系统性红斑狼疮中双胞胎一致性的修订估计。

A revised estimate of twin concordance in systemic lupus erythematosus.

作者信息

Deapen D, Escalante A, Weinrib L, Horwitz D, Bachman B, Roy-Burman P, Walker A, Mack T M

机构信息

Department of Preventive Medicine, University of Southern California School of Medicine 90033.

出版信息

Arthritis Rheum. 1992 Mar;35(3):311-8. doi: 10.1002/art.1780350310.

DOI:10.1002/art.1780350310

PMID:1536669

Abstract

OBJECTIVE

Based on a small clinical series and previously published case reports, concordance for systemic lupus erythematosus (SLE) among monozygous (MZ) twins has been reported to be as high as 69%. Using a larger and less biased sample, we provide another estimate of this percentage.

METHODS

We established a registry of twins with SLE, based upon self-reports and information provided by the patients' physicians. We used DNA fingerprinting to validate the reported zygosity in a sample of these twins.

RESULTS

Of 107 twin pairs meeting the American College of Rheumatology 1982 revised criteria for the diagnosis of SLE, 24% of 45 MZ pairs and 2% of 62 dizygous (DZ) pairs were concordant. The frequency distributions of diagnostic criteria and disease symptoms in the SLE patients were similar to those in other published reports of SLE patients. Zygosity was confirmed by DNA fingerprinting in a subsample of 15 self-described MZ twins and 7 self-described DZ twins. All individuals had correctly predicted their zygosity.

CONCLUSION

MZ concordance for SLE is similar to that for other autoimmune diseases and is much lower than previously believed.

摘要

目的

基于一个小型临床系列研究和先前发表的病例报告，据报道单卵双胞胎（MZ）中系统性红斑狼疮（SLE）的一致性高达69%。我们使用一个更大且偏差更小的样本，给出了该百分比的另一个估计值。

方法

我们基于患者的自我报告和其医生提供的信息，建立了一个SLE双胞胎登记册。我们使用DNA指纹图谱技术在这些双胞胎的一个样本中验证所报告的合子性。

结果

在符合美国风湿病学会1982年修订的SLE诊断标准的107对双胞胎中，45对MZ双胞胎中有24%、62对异卵双胞胎（DZ）中有2%是一致的。SLE患者的诊断标准和疾病症状的频率分布与其他已发表的SLE患者报告中的相似。通过DNA指纹图谱技术在15对自认为是MZ的双胞胎和7对自认为是DZ的双胞胎的一个子样本中确认了合子性。所有个体都正确预测了自己的合子性。