Van Haastert Peter J M, Devreotes Peter N
Department of Biochemistry, University of Groningen, Nijenborgh 4, 9747AG Groningen, The Netherlands.
Nat Rev Mol Cell Biol. 2004 Aug;5(8):626-34. doi: 10.1038/nrm1435.
During random locomotion, human neutrophils and Dictyostelium discoideum amoebae repeatedly extend and retract cytoplasmic processes. During directed cell migration--chemotaxis--these pseudopodia form predominantly at the leading edge in response to the local accumulation of certain signalling molecules. Concurrent changes in actin and myosin enable the cell to move towards the stimulus. Recent studies are beginning to identify an intricate network of signalling molecules that mediate these processes, and how these molecules become localized in the cell is now becoming clear.
在随机运动过程中，人类中性粒细胞和盘基网柄菌变形虫会反复伸展和缩回细胞质突起。在细胞定向迁移（趋化作用）过程中，这些伪足主要在前沿形成，以响应某些信号分子的局部积累。肌动蛋白和肌球蛋白的同时变化使细胞能够朝着刺激源移动。最近的研究开始确定介导这些过程的复杂信号分子网络，并且这些分子如何在细胞中定位现在也逐渐清晰。
