Janmey Paul A, Lindberg Uno
Institute for Medicine and Engineering, University of Pennsylvania, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, Pennsylvania 19104, USA.
Nat Rev Mol Cell Biol. 2004 Aug;5(8):658-66. doi: 10.1038/nrm1434.
Phosphorylated derivatives of the phospholipid phosphatidylinositol, or phosphoinositides, are implicated in many aspects of cell function. Binding of phosphoinositides that are localized within cell membranes to soluble protein ligands allows spatially selective regulation at the cytoplasm-membrane interface. Recently, studies that relate phosphoinositide production to membrane domains are converging with those that show effects of these lipids on the assembly of cellular actin, and are therefore linking membrane and cytoskeletal structures in new ways.
磷脂酰肌醇的磷酸化衍生物，即磷酸肌醇，参与细胞功能的许多方面。定位于细胞膜内的磷酸肌醇与可溶性蛋白质配体的结合允许在细胞质-膜界面进行空间选择性调节。最近，将磷酸肌醇产生与膜结构域相关联的研究，正与那些显示这些脂质对细胞肌动蛋白组装有影响的研究趋于一致，因此正以新的方式将膜结构和细胞骨架结构联系起来。
