镍催化的炔烃与异氰酸酯的环加成反应。
Nickel-catalyzed cycloaddition of alkynes and isocyanates.
作者信息
Duong Hung A, Cross Michael J, Louie Janis
机构信息
Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112-0850, USA.
出版信息
J Am Chem Soc. 2004 Sep 22;126(37):11438-9. doi: 10.1021/ja046477i.
PMID:15366880
Abstract
A mild and general route for preparing 2-pyridones from isocyanates and diynes is described. Ni imidazolyidene complexes were used to mediate cyclizations between both internal and terminal diynes with aryl and alkyl isocyanates. In addition, the efficacy of this protocol allows for the preparation of a fused seven-membered pyridone and for three component cyclizations.
摘要
本文描述了一种由异氰酸酯和二炔制备2-吡啶酮的温和通用方法。镍咪唑亚基配合物用于介导内炔和端炔与芳基和烷基异氰酸酯之间的环化反应。此外，该方法的有效性还可用于制备稠合七元吡啶酮以及进行三组分环化反应。
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