铁催化的炔腈和氰胺构建 2-氨基嘧啶。
The iron-catalyzed construction of 2-aminopyrimidines from alkynenitriles and cyanamides.
机构信息
The University of Utah, 315 S. 1400 E. RM. 2020, Salt Lake City, UT 84102, USA.
出版信息
Chem Commun (Camb). 2013 Sep 11;49(70):7735-7. doi: 10.1039/c3cc44422h.
Abstract
Several cycloaddition catalysts and reagents were surveyed for their effectiveness toward cyclizing alkynenitriles with cyanamides. Catalytic amounts of FeI2, (iPr)PDAI and Zn were found to effectively catalyze the [2+2+2] cycloaddition of a variety of cyanamides and alkynenitriles to afford bicyclic 2-aminopyrimidines.
摘要
几种环加成催化剂和试剂被考察了其对炔腈与氰酰胺环加成的效果。发现催化量的 FeI2、(iPr)PDAI 和 Zn 可以有效地催化各种氰酰胺和炔腈的[2+2+2]环加成反应，得到双环 2-氨基嘧啶。
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