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[Inhibitory effects of HLA-derived peptide RDP1258 on proliferation and heme oxygenase-1 activity of rat splenocytes].

作者信息

Yi Shan-hong, Song Bo, Wang Ze-hou, Zhang Gen-fu, Cui Zhi-gang

机构信息

Department of Urology, Xingqiao Hospital, Third Military Medical University, Chongqing, 400037, China.

出版信息

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2004 Sep;20(5):632-4.

PMID:15367367
Abstract

AIM

To observe the immunosuppression effect of a novel HLA-derived peptide RDP1258, and to explore its mechanisms.

METHODS

RDP1258 was synthesized chemically. The effect of the peptide on alloreactive proliferation of rat splenocytes was observed by (3)H-TdR incorporation method. The heme oxygenase-1(HO-1) activity was analyzed by the enzyme assay.

RESULTS

The results showed that the synthetic HLA-derived peptide could obviously inhibit the proliferation of rat splenocytes and HO-1 activity in a dose-dependent manner in-vitro.

CONCLUSION

HO-1 may participate in the inhibitory effect of RDP1258 on the proliferation of rat splenocytes induced by mitogen or alloantigen.

摘要

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