McCollum David L, Greene Jerica L, McGuire Darren K
Department of Internal Medicine, The University of Texas-Southwestern Medical Center at Dallas, Dallas,Texas, USA.
Cardiovasc Drugs Ther. 2004 Jul;18(4):329-30. doi: 10.1023/B:CARD.0000041254.15807.98.
Bupropion is an increasingly prescribed agent to aid in smoking cessation. However it has important drug-drug interactions related to the cytochrome P450 system. One of these is its inhibition of the metabolism of the commonly used beta-blocker, metoprolol. The authors describe a case of severe bradycardia related to the addition of bupropion to the medical regimen of a patient on metoprolol.
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