König F, Häfele M, Hauger B, Löble M, Wössner S, Wolfersdorf M
Abteilung Psychiatrie I, Universität Ulm, Ravensburg.
Psychiatr Prax. 1996 Sep;23(5):244-5.
Because of their low incidence of adverse effects SSRI are prescribed more and more frequently in patients with depressive disorders. SSRI inhibit different subsystems of cytochrome-P 450-oxydase. Especially during co-administration of SSRI with antipsychotic and antiarrhythmic drugs pharmacokinetic interactions have to be observed carefully. In this presentation a case of bradycardia after co-administration of paroxetine and metoprolol is reported. Drug history and a careful drug monitoring are necessary requirements to avoid serious adverse effects.
由于选择性5-羟色胺再摄取抑制剂（SSRI）不良反应发生率较低，越来越频繁地被用于治疗抑郁症患者。SSRI抑制细胞色素P 450氧化酶的不同子系统。尤其是在SSRI与抗精神病药物和抗心律失常药物合用时，必须仔细观察药代动力学相互作用。在本报告中，报道了1例帕罗西汀与美托洛尔合用时发生心动过缓的病例。用药史和仔细的药物监测是避免严重不良反应的必要条件。
