立体定向神经外科手术对帕金森病姿势不稳和步态的影响。
Effects of stereotactic neurosurgery on postural instability and gait in Parkinson's disease.
作者信息
Bakker Maaike, Esselink Rianne A J, Munneke Marten, Limousin-Dowsey Patricia, Speelman Hans D, Bloem Bastiaan R
机构信息
Department of Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands.
出版信息
Mov Disord. 2004 Sep;19(9):1092-9. doi: 10.1002/mds.20116.
Postural instability and gait disability (PIGD) are disabling signs of Parkinson's disease. Stereotactic surgery aimed at the internal globus pallidus (GPi) or subthalamic nucleus (STN) might improve PIGD, but the precise effects remain unclear. We performed a systematic review of studies that examined the effects of GPi or STN surgery on PIGD. Most studies examined the effects of bilateral GPi stimulation, bilateral STN stimulation, and unilateral pallidotomy; we, therefore, only performed a meta-analysis on these studies. Bilateral GPi stimulation, bilateral STN stimulation, and to a lesser extent, unilateral pallidotomy significantly improved PIGD, and more so during the ON phase than during the OFF phase.
姿势不稳和步态障碍（PIGD）是帕金森病的致残症状。针对内侧苍白球（GPi）或丘脑底核（STN）的立体定向手术可能会改善PIGD，但确切效果仍不清楚。我们对研究GPi或STN手术对PIGD影响的研究进行了系统综述。大多数研究考察了双侧GPi刺激、双侧STN刺激和单侧苍白球切开术的效果；因此，我们仅对这些研究进行了荟萃分析。双侧GPi刺激、双侧STN刺激，以及在较小程度上，单侧苍白球切开术均显著改善了PIGD，且在“开”期的改善程度大于“关”期。
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