临床实践中帕金森病深部脑刺激的基础：第1部分。
Fundamentals of deep brain stimulation for Parkinson's disease in clinical practice: part 1.
作者信息
Aquino Camila Henriques de, Moscovich Mariana, Marinho Murilo Martinez, Barcelos Lorena Broseghini, Felício André C, Halverson Matthew, Hamani Clement, Ferraz Henrique Ballalai, Munhoz Renato Puppi
机构信息
University of Calgary, Cumming School of Medicine, Department of Clinical Neurosciences, Calgary, AB, Canada.
University of Calgary, Hotchkiss Brain Institute, Calgary, AB, Canada.
出版信息
Arq Neuropsiquiatr. 2024 Apr;82(4):1-9. doi: 10.1055/s-0044-1786026. Epub 2024 Apr 23.
Deep brain stimulation (DBS) is recognized as an established therapy for Parkinson's disease (PD) and other movement disorders in the light of the developments seen over the past three decades. Long-term efficacy is established for PD with documented improvement in the cardinal motor symptoms of PD and levodopa-induced complications, such as motor fluctuations and dyskinesias. Timing of patient selection is crucial to obtain optimal benefits from DBS therapy, before PD complications become irreversible. The objective of this first part review is to examine the fundamental concepts of DBS for PD in clinical practice, discussing the historical aspects, patient selection, potential effects of DBS on motor and non-motor symptoms, and the practical management of patients after surgery.
鉴于过去三十年所取得的进展，深部脑刺激术（DBS）被公认为是治疗帕金森病（PD）和其他运动障碍的一种成熟疗法。对于帕金森病，其长期疗效已得到确立，有记录表明，帕金森病的主要运动症状以及左旋多巴引起的并发症（如运动波动和异动症）均有改善。在帕金森病并发症变得不可逆转之前，选择合适的患者时机对于从DBS治疗中获得最佳疗效至关重要。本综述第一部分的目的是探讨临床实践中用于帕金森病的DBS的基本概念，讨论其历史背景、患者选择、DBS对运动和非运动症状的潜在影响以及术后患者的实际管理。
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