Schwartz R A, Burgess G H
Arch Dermatol. 1978 Dec;114(12):1803-6.
The abrupt onset of acanthosis nigricans (AN) or of multiple seborrheic keratoses in middle-aged or older people is often associated with underlying malignant neoplasms. We describe a 64-year-old woman who developed a large number of verrucous papillomas on the trunk and extremities, followed within a few months by the sudden appearance of both the lesions of AN and those of multiple seborrheic keratoses. Laparotomy disclosed a gastric adenocarcinoma. A number of similar cases have been described in the literature. It is emphasized that patients with suddenly appearing verrucous papillomas should be examined carefully for an underlying cancer. To call attention to this eruption, which may be mistaken for generalized warts, we suggest the term "florid cutaneous papillomatosis".
中年或老年人黑棘皮病(AN)或多发性脂溢性角化病的突然出现通常与潜在的恶性肿瘤有关。我们描述了一名64岁女性,其躯干和四肢出现大量疣状乳头瘤,几个月内又突然出现了AN病变和多发性脂溢性角化病病变。剖腹探查发现胃腺癌。文献中已描述了许多类似病例。需要强调的是,对于突然出现疣状乳头瘤的患者,应仔细检查是否存在潜在癌症。为引起对这种可能被误诊为泛发性疣的皮疹的关注,我们建议使用“ florid cutaneous papillomatosis”(繁茂性皮肤乳头瘤病)这一术语。