Janier M, Blanchet-Bardon C, Bonvalet D, Lenoble M, Boiget F, Civatte J
Clinique des maladies cutanées et syphilitiques, Hôpital Saint-Louis, Paris, France.
Dermatologica. 1988;176(3):133-7.
Two cases of malignant acanthosis nigricans associated with non-Hodgkin's lymphoma are presented. A 61-year-old negro male with a diffuse large cell non-Hodgkin's lymphoma presented extensive acanthosis nigricans, pachydermatoglyphy and florid cutaneous papillomatosis. No viral particles were observed by electron microscopic studies of the wart-like lesions. Acanthosis nigricans disappeared under chemotherapy. The second case was a 21-year-old caucasian male with non T non B diffuse large cell non-Hodgkin's lymphoma. Very few cases of acanthosis nigricans associated with non-Hodgkin's lymphoma have been reported in the literature, since to our knowledge these two are only the fourth and fifth. Pachydermatoglyphy and florid cutaneous papillomatosis are markers of malignant acanthosis nigricans.
本文报告了两例与非霍奇金淋巴瘤相关的恶性黑棘皮病病例。一名61岁的黑人男性患有弥漫性大细胞非霍奇金淋巴瘤，表现为广泛的黑棘皮病、厚皮性皮纹症和皮肤乳头瘤病。对疣状病变进行电子显微镜研究未观察到病毒颗粒。化疗后黑棘皮病消失。第二例是一名21岁的白种男性，患有非T非B弥漫性大细胞非霍奇金淋巴瘤。文献中报道的与非霍奇金淋巴瘤相关的黑棘皮病病例很少，据我们所知，这两例是第四例和第五例。厚皮性皮纹症和皮肤乳头瘤病是恶性黑棘皮病的标志。
