Pentenero M, Carrozzo M, Pagano M, Gandolfo S
Department of Biomedical Sciences and Human Oncology, Oral Medicine Section, and Surgical Pathology Section, University of Turin, Turin, Italy.
Int J Dermatol. 2004 Jul;43(7):530-2. doi: 10.1111/j.1365-4632.2004.02159.x.
Acanthosis nigricans (AN), tripe palms (TP) and the sign of Leser-Trélat (LT) may be seen with the presence of malignancy. Acanthosis nigricans may have a mucocutaneous localization involving the oral mucosa with papillomatous and verrucous lesions usually on the lips and buccal mucosa. These paraneoplastic dermatoses are generally linked with intra-abdominal malignancy, most often gastric adenocarcinoma. Improvement of the associated dermatoses after the treatment of the malignancy has been frequently observed. We report the case of a 53-year-old man suffering from advanced gastric adenocarcinoma, in which metastases seemed to sustain all three paraneoplastic dermatoses. To the best of our knowledge this is the first case of a patient showing manifestations of all three paraneoplastic dermatoses. Patients presenting with this set of dermatoses should be suspected to harbor an occult malignancy, or have persistence of a known malignancy.
恶性肿瘤存在时可能会出现黑棘皮病（AN）、掌跖角化病（TP）和Leser-Trélat征（LT）。黑棘皮病可能有黏膜皮肤定位，累及口腔黏膜，通常在嘴唇和颊黏膜出现乳头状和疣状病变。这些副肿瘤性皮肤病一般与腹内恶性肿瘤有关，最常见的是胃腺癌。恶性肿瘤治疗后相关皮肤病有所改善的情况屡见不鲜。我们报告了一例53岁患有晚期胃腺癌的男性病例，其中转移似乎维持了所有三种副肿瘤性皮肤病。据我们所知，这是首例出现所有三种副肿瘤性皮肤病表现的患者。出现这组皮肤病的患者应怀疑患有隐匿性恶性肿瘤，或已知恶性肿瘤持续存在。
