Py235蛋白：洞察疟疾多基因家族的多功能性
The Py235 proteins: glimpses into the versatility of a malaria multigene family.
作者信息
Grüner Anne Charlotte, Snounou Georges, Fuller Katy, Jarra William, Rénia Laurent, Preiser Peter R
机构信息
Département d'Immunologie, Institut Cochin, Inserm U567, CNRS UMR 8104, Université René Descartes, Hôpital Cochin, 27 rue du Faubourg Saint Jacques, 75014 Paris, France.
出版信息
Microbes Infect. 2004 Jul;6(9):864-73. doi: 10.1016/j.micinf.2004.04.004.
Py235 rhoptry proteins, encoded by a multigene family of the rodent malaria parasite Plasmodium yoelii, combine a functional role in invasion with one of immune evasion, and have homologues in malaria parasites of humans. Investigations of Py235 are summarised and the perspectives for dissecting the molecular and biological mechanisms underlying these crucial phenomena are discussed.
约氏疟原虫（Plasmodium yoelii）的多基因家族编码的Py235棒状体蛋白，在入侵过程中发挥功能作用，同时具有免疫逃避功能，并且在人类疟原虫中存在同源物。本文总结了对Py235的研究，并讨论了剖析这些关键现象背后分子和生物学机制的前景。
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