巴西阴茎肿瘤组织中爱泼斯坦-巴尔病毒（EBV）DNA的检测与表达

Detection and expression of Epstein-Barr Virus (EBV) DNA in tissues from penile tumors in Brazil.

作者信息

Alves Gilda, Macrini Camila Menezes Trindade, de Souza Nascimento Patrícia, Morais José Carlos, Ornellas Antonio Augusto

机构信息

Serviço de Hematologia, HC I, Instituto Nacional de Câncer, Pç. da Cruz Vermelha, 23, 8 andar, 20230-130 Rio de Janeiro, RJ, Brazil.

出版信息

Cancer Lett. 2004 Nov 8;215(1):79-82. doi: 10.1016/j.canlet.2004.04.025.

DOI:10.1016/j.canlet.2004.04.025

PMID:15374635

Abstract

Epstein-Barr Virus (EBV) is prevalent in all human populations and high titers of antibody correlate with specific malignancies such as Burkitt's lymphoma, nasopharyngeal carcinoma, and Hodgkin's disease. Our study detected EBV DNA in 20 of 21 penile tumor samples using PCR reaction. Expression of EBV protein LMP-1 was identified in tumor cells from two EBV PCR-positive tumors. Our findings indicate that EBV can be implicated in rising and/or progression of penile tumors independently of the histological type.

摘要

爱泼斯坦-巴尔病毒（EBV）在所有人群中都很普遍，高滴度抗体与特定恶性肿瘤相关，如伯基特淋巴瘤、鼻咽癌和霍奇金病。我们的研究使用PCR反应在21个阴茎肿瘤样本中的20个中检测到了EBV DNA。在两个EBV PCR阳性肿瘤的肿瘤细胞中鉴定出了EBV蛋白LMP-1的表达。我们的研究结果表明，EBV可能与阴茎肿瘤的发生和/或进展有关，而与组织学类型无关。