正常脑衰老过程中的钙离子调节与基因表达

Ca2+ regulation and gene expression in normal brain aging.

作者信息

Toescu Emil C, Verkhratsky Alexei, Landfield Philip W

机构信息

Department of Physiology, Division of Medical Sciences, The University of Birmingham, Edgbaston B15 2TT, UK.

出版信息

Trends Neurosci. 2004 Oct;27(10):614-20. doi: 10.1016/j.tins.2004.07.010.

DOI:10.1016/j.tins.2004.07.010

PMID:15374673

Abstract

Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca(2+) influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca(2+) regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.

摘要

对于神经科学界来说，了解表征衰老大脑功能变化的细胞机制是一项持续且艰巨的挑战。目前有证据表明，钙离子内流和内环境稳态的变化与衰老过程所引发的、参与钙离子调节的主要细胞内细胞器（内质网和线粒体）功能扰动有关。近期的基因微阵列研究也提供了新的视角，阐明了衰老过程的多因素性质。