Romagnoli Anna, Aguiari Paola, De Stefani Diego, Leo Sara, Marchi Saverio, Rimessi Alessandro, Zecchini Erika, Pinton Paolo, Rizzuto Rosario
ER-GenTech and Interdisciplinary Center for the Study of Inflammation, Department of Experimental and Diagnostic Medicine, University of Ferrara, Italy.
Novartis Found Symp. 2007;287:122-31; discussion 131-9.
The interaction of mitochondria with the endoplasmic reticulum (ER) Ca2+ store plays a key role in allowing these organelles to rapidly and effectively respond to cellular Ca2+ signals. In this contribution, we will briefly discuss: (i) old and new concepts of mitochondrial Ca2+ homeostasis; (ii) the relationship between mitochondrial 3D structure and Ca2+ homeostasis; (iii) the modulation by cytoplasmic signalling pathways; and (iv) new data suggesting that mitochondria and ER Ca2+ channels are assembled in a macromolecular complex in which the inositol-1,4,5-trisphosphate receptor directly stimulates the mitochondrial Ca2+ uptake machinery.
线粒体与内质网（ER）钙库的相互作用在使这些细胞器快速有效地响应细胞钙信号方面起着关键作用。在本论文中，我们将简要讨论：（i）线粒体钙稳态的新旧概念；（ii）线粒体三维结构与钙稳态之间的关系；（iii）细胞质信号通路的调节作用；以及（iv）新数据表明线粒体和内质网钙通道组装成一个大分子复合物，其中肌醇-1,4,5-三磷酸受体直接刺激线粒体钙摄取机制。
