由野生型染色体与线性质粒scp1单交换产生的天蓝色链霉菌A3(2)的两条嵌合染色体。
Two chimeric chromosomes of Streptomyces coelicolor A3(2) generated by single crossover of the wild-type chromosome and linear plasmid scp1.
作者信息
Yamasaki Masayuki, Kinashi Haruyasu
机构信息
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi-Hiroshima, Japan.
出版信息
J Bacteriol. 2004 Oct;186(19):6553-9. doi: 10.1128/JB.186.19.6553-6559.2004.
Abstract
Streptomyces coelicolor A3(2) strain 2106 carries a 1.85-Mb linear plasmid, SCP1'-cysD, in addition to a 7.2-Mb linear chromosome. Macrorestriction analysis indicated that both linear DNAs are hybrids of the wild-type chromosome and the linear plasmid SCP1 on each side. Nucleotide sequencing of the fusion junctions revealed no homology between the recombination regions. SCP1'-cysD contains an SCP1 telomere and a chromosomal telomere at each end and therefore does not have terminal inverted repeats. In addition, SCP1'-cysD could not be eliminated from strain 2106 by various mutagenic treatments. Thus, we concluded that both the 7.2-Mb chromosome and SCP1'-cysD are chimeric chromosomes generated by a single crossover of the wild-type chromosome and SCP1. This may be regarded as a model of chromosomal duplication in genome evolution.
摘要
天蓝色链霉菌A3(2)菌株2106除了含有一条7.2 Mb的线性染色体外，还携带一个1.85 Mb的线性质粒SCP1'-cysD。宏观限制性分析表明，两条线性DNA在两侧均为野生型染色体与线性质粒SCP1的杂种。融合连接点的核苷酸测序显示，重组区域之间没有同源性。SCP1'-cysD在两端各含有一个SCP1端粒和一个染色体端粒，因此没有末端反向重复序列。此外，通过各种诱变处理无法从菌株2106中消除SCP1'-cysD。因此，我们得出结论，7.2 Mb的染色体和SCP1'-cysD都是由野生型染色体和SCP1的单次交叉产生的嵌合染色体。这可以被视为基因组进化中染色体复制的一个模型。
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