Gluckman Peter D, Hanson Mark A
Liggins Institute, University of Auckland and National Research Centre for Growth and Development, 2-6 Park Avenue, Grafton, Private Bag 92019, Auckland, New Zealand.
Science. 2004 Sep 17;305(5691):1733-6. doi: 10.1126/science.1095292.
Epidemiological observations have led to the hypothesis that the risk of developing some chronic noncommunicable diseases in adulthood is influenced not only by genetic and adult life-style factors but also by environmental factors acting in early life. Research in evolutionary biology, developmental biology, and animal and human physiology provides support for this idea and suggests that environmental processes influencing the propensity to disease in adulthood operate during the periconceptual, fetal, and infant phases of life. This "developmental origins of health and disease" concept may have important biological, medical, and socioeconomic implications.
成年后患某些慢性非传染性疾病的风险不仅受到遗传因素和成年生活方式因素的影响，还受到生命早期环境因素的作用。进化生物学、发育生物学以及动物和人体生理学的研究为这一观点提供了支持，并表明影响成年期疾病易感性的环境过程在生命的受孕前期、胎儿期和婴儿期发挥作用。这种“健康与疾病的发育起源”概念可能具有重要的生物学、医学和社会经济意义。
