Kusakabe T, Hirakawa H, Oikawa S, Matsuda H, Kawakami T, Takenaka T, Hayashida Y
Laboratory for Anatomy and Physiology, Department of Sport and Medical Science, Kokushikan University, Tokyo.
Histol Histopathol. 2004 Oct;19(4):1133-40. doi: 10.14670/HH-19.1133.
Morphological changes in the rat carotid bodies 1, 2, 4, and 8 weeks after the termination of chronically hypocapnic hypoxia (10% O2 for 8 weeks) were examined by means of morphometry and immunohistochemistry. The rat carotid bodies after 8 weeks of hypoxic exposure were enlarged several fold with vascular expansion. The carotid bodies 1 and 2 weeks after the termination of 8 weeks of hypoxic exposure were diminished in size, although their diameter remained larger than the normoxic controls. The expanded vasculature in chronically hypoxic carotid bodies returned to the normoxic control state. In the carotid bodies 1 week after the termination of chronic hypoxia, the density of NPY fibers was remarkably increased and that of VIP fibers was dramatically decreased in comparison with the density in chronically hypoxic carotid bodies. In the carotid bodies 2 and 4 weeks after the termination of hypoxia, the density of SP and CGRP fibers was gradually increased. In the carotid bodies 8 weeks after the termination of hypoxia, the appearance of the carotid body returned to a nearly normoxic state, and the density of SP, CGRP, VIP, and NPY fibers also recovered to that of normoxic controls. These results suggest that the morphological changes in the recovering carotid bodies start at a relatively early period after the termination of chronic hypoxia, and a part of these processes may be under the control of peptidergic innervation.
通过形态计量学和免疫组织化学方法，研究了慢性低碳酸血症性缺氧（8周10%氧气）终止后1、2、4和8周大鼠颈动脉体的形态学变化。缺氧暴露8周后的大鼠颈动脉体因血管扩张而增大了几倍。在8周缺氧暴露终止后1周和2周的颈动脉体，其大小减小，尽管其直径仍大于常氧对照组。慢性缺氧颈动脉体中扩张的血管系统恢复到常氧对照状态。与慢性缺氧颈动脉体中的密度相比，在慢性缺氧终止后1周的颈动脉体中，NPY纤维密度显著增加，VIP纤维密度显著降低。在缺氧终止后2周和4周的颈动脉体中，SP和CGRP纤维密度逐渐增加。在缺氧终止后8周的颈动脉体中，颈动脉体的外观恢复到几乎常氧状态，SP、CGRP、VIP和NPY纤维的密度也恢复到常氧对照组的水平。这些结果表明，恢复中的颈动脉体的形态学变化在慢性缺氧终止后的相对早期就开始了，并且这些过程的一部分可能受肽能神经支配的控制。
