Kina Hakan, Apaydin Aydın Sinan
Department of Neurosurgery, Faculty of Medicine, İstinye University, İstanbul, Turkiye.
Department of Neurosurgery, Faculty of Medicine, Karabük University, Karabük, Turkiye.
Turk J Med Sci. 2024 Dec 12;55(1):223-230. doi: 10.55730/1300-0144.5961. eCollection 2025.
The carotid artery is the main artery supplying blood to the brain. Carotid bodies (CB), located at the bifurcation of the carotid artery, regulate blood pH. This study aimed to assess the changes in CB-related pH levels following degeneration induced by ligation of both common carotid arteries (CCA).
We included 23 adult male New Zealand rabbits in the study. The animals were divided into three groups: a control group (n = 5), a sham group (saline injection, n = 5), and a study group subjected to bilateral CCA ligation (n = 13). pH levels and cardiac rhythms were monitored before, during, and after the procedure at two-day intervals over three weeks. Additionally, we quantified both healthy and degenerated neuron densities in the CB.
Initial pH levels were as follows: control group (7.42 ± 0.039), sham (7.39 ± 0.059), and study group (7.35 ± 0 .12). Prior to euthanasia, pH levels were the following: control (7.40 ± 0.029), sham (7.42 ± 0.041), and study (7.39 ± 0.12). The density of degenerated neurons in the CB was as follows: control (11 ± 4/mm), sham (394 ± 74/mm), and study (1363 ± 347/mm). Statistical analysis showed the following significant differences: control vs. sham (p < 0.001), sham vs. study (p < 0.0005), and control vs. study (p < 0.000001).
Increased degenerated neuron density in CB leads to reduced blood pH following CCA ligation due to acute ischemia of CB. Timely pH normalization occurs as vertebrobasilar reverse blood flow supplies CB, reversing neurodegeneration and normalizing pH.
颈动脉是向大脑供血的主要动脉。位于颈动脉分叉处的颈动脉体（CB）调节血液pH值。本研究旨在评估双侧颈总动脉（CCA）结扎诱导变性后CB相关pH水平的变化。
我们纳入了23只成年雄性新西兰兔进行研究。动物被分为三组：对照组（n = 5）、假手术组（注射生理盐水，n = 5）和接受双侧CCA结扎的研究组（n = 13）。在手术前、手术期间和手术后，以两天为间隔，持续三周监测pH水平和心律。此外，我们对CB中健康和变性神经元密度进行了量化。
初始pH水平如下：对照组（7.42±0.039）、假手术组（7.39±0.059）和研究组（7.35±0.12）。在安乐死之前，pH水平如下：对照组（7.40±0.029）、假手术组（7.42±0.041）和研究组（7.39±0.12）。CB中变性神经元的密度如下：对照组（11±4/mm）、假手术组（394±74/mm）和研究组（1363±347/mm）。统计分析显示以下显著差异：对照组与假手术组（p < 0.001）、假手术组与研究组（p < 0.0005）以及对照组与研究组（p < 0.000001）。
CB中变性神经元密度增加导致CCA结扎后由于CB急性缺血而使血液pH值降低。随着椎基底动脉逆向血流供应CB，逆转神经变性并使pH值正常化，pH值及时恢复正常。
