Vikram Naval K, Misra Anoop, Pandey R M, Dwivedi Manjari, Luthra Kalpana
Department of Medicine, All India Institute of Medical Sciences, New Delhi.
Metabolism. 2004 Oct;53(10):1336-41. doi: 10.1016/j.metabol.2004.05.010.
High-sensitivity C-reactive protein (hs-CRP) levels are closely associated with adiposity and predict coronary heart disease and type 2 diabetes mellitus. However, relationships of CRP to adiponectin and other markers of insulin resistance have been inadequately researched in children. We measured fasting serum levels of adiponectin, insulin, hs-CRP, and lipoproteins, and recorded the anthropometric profile and percentage of body fat (%BF; bioimpedance method) in 62 (36 normal weight, 26 overweight) healthy, urban, postpubertal Asian Indian males (aged 14 to 18 years). Serum levels of adiponectin were lower (P = not significant [NS]), whereas those of fasting insulin (P = .01) and hs-CRP (P = .02) were higher in overweight subjects. Adiponectin levels inversely correlated with body mass index (BMI; r = -0.26, P < .05), %BF (r = -0.24, P < .05), fasting insulin (r = -0.32, P < .05) and insulin resistance measured by the homeostasis model of assessment (HOMA-IR; r = -0.31, P < .05), but not with hs-CRP levels. Fasting insulin and hs-CRP levels correlated significantly with BMI, %BF, waist circumference (WC), waist-to-hip circumference ratio (W-HR), and triceps and subscapular skinfold thickness. The correlation of adiponectin with insulin sensitivity was independent of abdominal obesity, but became nonsignificant after controlling for BMI and %BF. Further, BMI was an independent predictor of adiponectin levels and the ratio of adiponectin and %BF was an independent predictor of fasting insulin levels. Although adiponectin levels did not correlate with hs-CRP levels, we observed dichotomous relationships of adiponectin and hs-CRP levels with generalized and abdominal obesity, respectively. We conclude that generalized obesity affects the adiponectin-insulin relationship in postpubertal Asian Indian males; however, the relationship of adiponectin with hs-CRP needs further evaluation.
高敏C反应蛋白（hs-CRP）水平与肥胖密切相关，并可预测冠心病和2型糖尿病。然而，儿童中CRP与脂联素及其他胰岛素抵抗标志物之间的关系尚未得到充分研究。我们测量了62名（36名体重正常，26名超重）健康的、来自城市的、青春期后的亚洲印度男性（年龄14至18岁）的空腹血清脂联素、胰岛素、hs-CRP和脂蛋白水平，并记录了人体测量学特征和体脂百分比（%BF；生物电阻抗法）。超重受试者的血清脂联素水平较低（P =无显著性差异[NS]），而空腹胰岛素（P = 0.01）和hs-CRP（P = 0.02）水平较高。脂联素水平与体重指数（BMI；r = -0.26，P < 0.05）、%BF（r = -0.24，P < 0.05）、空腹胰岛素（r = -0.32，P < 0.05）以及通过稳态模型评估（HOMA-IR；r = -0.31，P < 0.05）测量的胰岛素抵抗呈负相关，但与hs-CRP水平无关。空腹胰岛素和hs-CRP水平与BMI、%BF、腰围（WC）、腰臀围比（W-HR）以及肱三头肌和肩胛下皮褶厚度显著相关。脂联素与胰岛素敏感性的相关性独立于腹部肥胖，但在控制BMI和%BF后变得不显著。此外，BMI是脂联素水平的独立预测因子，脂联素与%BF的比值是空腹胰岛素水平的独立预测因子。虽然脂联素水平与hs-CRP水平无关，但我们分别观察到脂联素和hs-CRP水平与全身性肥胖和腹部肥胖的二分关系。我们得出结论，全身性肥胖影响青春期后亚洲印度男性的脂联素-胰岛素关系；然而，脂联素与hs-CRP的关系需要进一步评估。
