Singh Ravi Pratap, Chauhan Kalpana, Tripathi Alok, Choudhary Rekha
Associate Professor, Department of Biochemistry, Subharti Medical College, Meerut (UP) 250005, India.
Professor, Department of Microbiology, Subharti Medical College Meerut (UP) 250005, India.
Maedica (Bucur). 2024 Sep;19(3):494-501. doi: 10.26574/maedica.2024.19.3.494.
A cluster of metabolic indicators responsible to elevate the risk of high blood sugar, heart diseases along with stroke is called metabolic syndrome (MetS). Adipokines play critical roles in the formation and progression of these clusters of diseases. Adiponectin enhances fatty acid oxidation, prevents foam cell formation and improves lipid metabolism. In contrast, plasminogen activator inhibitor-1 (PAI-1) possesses pro-atherogenic properties. Carotid intima-media thickness (CIMT) is directly associated with an increased risk of myocardial infarction and stroke. Complete information about the association related to adipokines and CIMT in MetS of Indian population is lacking.
To evaluate the association of adipokine levels and PAI-1 with CIMT in MetS patients, including its components.
We performed a cross-sectional study and IDF criteria were used for the screening of MetS. A total of 164 subjects with MetS (88 males and 76 females) and 100 controls (54 males and 46 females) were enrolled. Serum levels of adiponectin and PAI-1 were measured using ELISA. A CIMT measurement of carotid arteries was also done. The relationship between various parameters was assessed by the Pearson correlation coefficient test.
The levels of adiponectin were lower (p < 0.001), while those of PAI-1 and CIMT were higher (p < 0.001) when we compared patients with controls. When the number of metabolic abnormalities increased, the levels of adiponectin decreased and those of PAI-1 increased. There was a strong negative association between PAI-1 levels and those of adiponectin (p <0.001).
Our findings indicate that elevated PAI-1 levels are associated with a higher probability of having MetS and negatively impact MetS-related components.
一组会增加高血糖、心脏病及中风风险的代谢指标被称为代谢综合征（MetS）。脂肪因子在这些疾病集群的形成和发展中起着关键作用。脂联素可增强脂肪酸氧化、防止泡沫细胞形成并改善脂质代谢。相比之下，纤溶酶原激活物抑制剂-1（PAI-1）具有促动脉粥样硬化特性。颈动脉内膜中层厚度（CIMT）与心肌梗死和中风风险增加直接相关。印度人群代谢综合征中关于脂肪因子与CIMT之间关联的完整信息尚缺。
评估代谢综合征患者中脂肪因子水平和PAI-1与CIMT及其各组成部分之间的关联。
我们开展了一项横断面研究，并采用国际糖尿病联盟（IDF）标准筛查代谢综合征。共纳入164例代谢综合征患者（88例男性和76例女性）及100例对照者（54例男性和46例女性）。采用酶联免疫吸附测定法（ELISA）检测血清脂联素和PAI-1水平。同时对颈动脉进行CIMT测量。通过Pearson相关系数检验评估各项参数之间的关系。
与对照组相比，患者的脂联素水平较低（p < 0.001），而PAI-1和CIMT水平较高（p < 0.001）。当代谢异常数量增加时，脂联素水平降低，PAI-1水平升高。PAI-1水平与脂联素水平之间存在强负相关（p <0.001）。
我们的研究结果表明，PAI-1水平升高与患代谢综合征的较高概率相关，并对代谢综合征相关组成部分产生负面影响
