Smith Bryan K, Sun Grace Y, Donahue Owen M, Thomas Tom R
Center for Physical Activity and Weight Management, Schiefelbusch Life Span Institute, University of Kansas, Lawrence, USA.
Metabolism. 2004 Oct;53(10):1365-71. doi: 10.1016/j.metabol.2004.05.012.
The purpose of this study was to examine changes in postprandial lipemia (PPL) in recreationally active males following aerobic exercise, omega-3 fatty acids (n-3FA) supplementation, and the combination of the two. PPL following a high-fat meal was measured in 10 recreationally active males (25 +/-1.5 years) under each of the following conditions: no exercise and no n-3 FA supplementation (control); exercise and no n-3FA supplementation (exercise); n-3FA supplementation and no exercise (n-3FA); and exercise and n-3 FA supplementation (combined). Blood was collected before the high-fat meal and at 2, 4, 6, and 8 hours after the meal to assess the PPL response. Supplementation consisted of 4.0 g of n-3FA per day for 5 weeks. Triglyceride (TG) peak response, the total area under the TG curve (TG-AUCT), and the incremental area under the TG curve (TG-AUCI) were used to define the PPL response. TG peak response was significantly reduced 38% by n-3FA supplementation and 50% by the combination of exercise and n-3FA supplementation. N-3FAs significantly reduced the TG-AUCT by 27% and by 42% when combined with exercise. When compared with the exercise trial, the TG-AUCT during the combined trial was significantly lower. Exercise, n-3FAs, and the combination significantly reduced the TG-AUCI by 40%, 42%, and 58%, respectively. These results suggest that the combination of exercise and n-3FA supplementation reduce PPL to a greater degree in recreationally active males when compared with the individual treatments.
本研究的目的是检测有氧运动、补充ω-3脂肪酸（n-3FA）以及二者联合作用后，有休闲运动习惯男性的餐后血脂异常（PPL）变化情况。在以下每种条件下，对10名有休闲运动习惯的男性（25±1.5岁）进行高脂肪餐后PPL测量：不运动且不补充n-3FA（对照组）；运动且不补充n-3FA（运动组）；补充n-3FA且不运动（n-3FA组）；运动且补充n-3FA（联合组）。在高脂肪餐前以及餐后2、4、6和8小时采集血液，以评估PPL反应。补充方式为每天补充4.0 g n-3FA，持续5周。甘油三酯（TG）峰值反应、TG曲线下总面积（TG-AUCT）和TG曲线下增量面积（TG-AUCI）用于定义PPL反应。补充n-3FA使TG峰值反应显著降低38%，运动与n-3FA联合补充使TG峰值反应显著降低50%。n-3FA使TG-AUCT显著降低27%，与运动联合时降低42%。与运动试验相比，联合试验期间的TG-AUCT显著更低。运动、n-3FA以及二者联合分别使TG-AUCI显著降低40%、42%和58%。这些结果表明，与单独治疗相比，运动与补充n-3FA联合可使有休闲运动习惯的男性的PPL降低幅度更大。
