丹麦温室工人队列中对细菌和真菌生物农药的IgE致敏：BIOGART研究
IgE sensitization to bacterial and fungal biopesticides in a cohort of Danish greenhouse workers: the BIOGART study.
作者信息
Doekes Gert, Larsen Preben, Sigsgaard Torben, Baelum Jesper
机构信息
Institute for Risk Assessment Sciences, University Utrecht, The Netherlands.
出版信息
Am J Ind Med. 2004 Oct;46(4):404-7. doi: 10.1002/ajim.20086.
BACKGROUND
The use of biopesticides in agriculture may implicate new risks of work-related allergic reactions.
METHODS
Sera were tested from the BIOGART project, a longitudinal respiratory health study among >300 Danish greenhouse workers. IgE was measured by enzyme immunoassay (EIA) with extracts of biopesticide products containing Bacillus thuringiensis (BT) or Verticillium lecanii (Vert).
RESULTS
Many sera had detectable IgE to BT (23-29%) or Vert (9-21%). IgE titers from the 2- and 3-year follow-up (n=230) were highly correlated, with discordant results in <15%. IgE titers to different BT, or to different Verticillium products were also significantly correlated (both r >0.70), whereas IgE anti-BT and anti-Verticillium showed no correlation at all.
CONCLUSIONS
Exposure to these microbial biopesticides may confer a risk of IgE-mediated sensitization. In future research there is a need to identify allergenic components in the preparations, perform studies on non-exposed controls and analyze the relation between sensitization and health parameters.
背景
在农业中使用生物农药可能会带来与工作相关的过敏反应的新风险。
方法
对BIOGART项目中的血清进行检测，该项目是一项针对300多名丹麦温室工人的纵向呼吸健康研究。通过酶免疫测定法（EIA），使用含有苏云金芽孢杆菌（BT）或蜡蚧轮枝菌（Vert）的生物农药产品提取物来测量IgE。
结果
许多血清中可检测到针对BT（23%-29%）或Vert（9%-21%）的IgE。2年和3年随访（n=230）的IgE滴度高度相关，不一致结果的比例小于15%。针对不同BT或不同蜡蚧轮枝菌产品的IgE滴度也显著相关（两者r>0.70），而抗BT IgE和抗Vert IgE之间完全没有相关性。
结论
接触这些微生物生物农药可能会带来IgE介导的致敏风险。在未来的研究中，需要确定制剂中的致敏成分，对未接触者进行对照研究，并分析致敏与健康参数之间的关系。
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