Allcock L M, Ullyart K, Kenny R A, Burn D J
Parkinson's Disease Research Unit, Department of Neurology, Sunderland Royal Hospital and Institute for Ageing and Health, University of Newcastle, Sunderland, UK.
J Neurol Neurosurg Psychiatry. 2004 Oct;75(10):1470-1. doi: 10.1136/jnnp.2003.029413.
The frequency of orthostatic hypotension (OH) in cohorts of patients recruited through hospital Parkinson's disease (PD) clinics ranges from 16% to 58%. However, hospital based cohorts may be subject to ascertainment bias. The aim of this study was to determine the frequency of OH in a community based population of PD patients and to determine the demographic features of patients with and without OH. Forty two (47%) of patients met the criteria for OH. Subjects with OH were older than those without OH, but there was no difference in PD disease duration or severity, MMSE or depression rating between the groups.
通过医院帕金森病(PD)诊所招募的患者队列中,体位性低血压(OH)的发生率在16%至58%之间。然而,基于医院的队列可能存在确诊偏倚。本研究的目的是确定社区PD患者群体中OH的发生率,并确定有OH和无OH患者的人口统计学特征。42名(47%)患者符合OH标准。有OH的受试者比没有OH的受试者年龄更大,但两组之间在PD病程、严重程度、简易精神状态检查表(MMSE)或抑郁评分方面没有差异。