Johnson A P, Mushtaq S, Warner M, Livermore D M
Antibiotic Resistance Monitoring and Reference Laboratory, Health Protection Agency, Specialist and Reference Microbiology Division, Colindale, London NW9 5HT, UK.
Int J Antimicrob Agents. 2004 Oct;24(4):315-9. doi: 10.1016/j.ijantimicag.2004.04.006.
The activity of daptomycin was assessed against 545 isolates of Gram-positive bacteria including enterococci, coagulase-positive and -negative staphylococci, beta-haemolytic streptococci, viridans streptococci and coryneforms. The panel of isolates was biased towards those with resistance to first-line antimicrobial agents and included linezolid-resistant enterococci and Staphylococcus aureus. MICs of daptomycin were < or =1mg/l for all the staphylococci, streptococci, and coryneforms, except for two isolates of Corynebacterium aquaticum, for which MICs were 8 mg/l. Daptomycin MICs were < or =2 and < or =4 mg/l for Enterococcus faecalis and Enterococcus faecium, respectively.
对545株革兰氏阳性菌进行了达托霉素活性评估，这些细菌包括肠球菌、凝固酶阳性和阴性葡萄球菌、β溶血性链球菌、草绿色链球菌和棒状杆菌。分离菌株偏向于那些对一线抗菌药物耐药的菌株，包括耐利奈唑胺的肠球菌和金黄色葡萄球菌。除两株水生棒状杆菌的最低抑菌浓度（MIC）为8mg/l外，所有葡萄球菌、链球菌和棒状杆菌的达托霉素MIC均≤1mg/l。粪肠球菌和屎肠球菌的达托霉素MIC分别≤2mg/l和≤4mg/l。
